Targeted Drug Discovery Against Blood-Feeding Parasite Nematodes of Animals

The developmental lipidome of Nippostrongylus brasiliensis

T Wang, MG Leeming, NA Williamson, T Bouchery, R Doolan, G Le Gros, GE Reid, NL Harris, RB Gasser

2025-12-01

Background: Nippostrongylus brasiliensis—a nematode of rodents—is commonly used as a model to study the immunobiology of parasitic..

Helminth infection driven gastrointestinal hypermotility is independent of eosinophils and mediated by alterations in smooth muscle instead of enteric neurons

Haozhe Wang, Kristian Barry, Aidil Zaini, Gillian Coakley, Mati Moyat, Carmel P Daunt, Lakshanie C Wickramasinghe, Rossana Azzoni, Roxanne Chatzis, Bibek Yumnam, Mali Camberis, Graham Le Gros, Olaf Perdijk, Jaime PP Foong, Joel C Bornstein, Benjamin J Marsland, Nicola L Harris

2024-08-01

Intestinal helminth infection triggers a type 2 immune response that promotes a 'weep-and sweep' response characterised by increas..

Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway

A Marchand, JWM Van Bree, AC Taki, M Moyat, G Turcatti, M Chambon, AAT Smith, R Doolan, RB Gasser, NL Harris, T Bouchery

2022-06-01

Hookworm infections cause a neglected tropical disease (NTD) affecting ~740 million people worldwide, principally those living in ..